Table 4. Univariate and multivariate analysis of prognostic parameters for survival in patients with CRC.

Prognostic parameter	Univariable analysis		Multivariable analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Expression of NOX4 (high vs. low)	3.342 (1.679–6.652)	0.001*	2.919 (1.382–6.163)	0.005*
Age (< 65 vs. ≥ 65)	1.186 (0.643–2.186)	0.585	–	–
Sex (male vs. female)	1.310 (0.702–2.443)	0.396	–	–
Tumor location (right hemicolon vs. left hemicolon)	0.862 (0.472–1.574)	0.629	–	–
Tumor size (< 5 cm vs. ≥ 5 cm)	2.218 (1.155–4.259)	0.017*	2.158 (1.101–4.231)	0.025*
T classification (T1 vs. T2 vs. T3 vs. T4)	1.723 (1.007–2.949)	0.047*	0.967 (0.562–1.663)	0.903
Lymph node metastasis (Absent vs. Present)	1.707 (0.931–3.130)	0.084	–	–
Distant metastasis (Absent vs. Present)	5.269 (2.307–12.033)	0.000*	3.209 (1.321–7.799)	0.010*
Tumor differentiation (Well/moderate vs. poor)	1.475 (0.769–2.831)	0.242	–	–

The bold number indicates the P-values with statistical significance. HR: Hazard ratio; CI: Confidence interval.