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. 2017 Apr 4;8(20):33601–33613. doi: 10.18632/oncotarget.16830

Figure 6. Disease pathobiology was evaluated following intratumoral injection of S. Typhimurium.

Figure 6

Six days following 4T1 tumor cell injections into the mammary fat pad, animals were administered either VNP20009 or VNP20009 cheY+ directly into mammary tumors. Similar parameters were assessed as in the previous intravenous experiment including (A) weight change, (B) calculated diameter of the primary mammary tumor, (C) histopathologic scoring of liver sections, and (D) number of bacterial cells recovered from the liver or primary tumor of infected animals. PBS control, n = 2; Tumor only, n = 4; VNP20009 and tumor, n = 6; VNP20009 cheY+ and tumor, n = 7. Error bars denote SEM for A and B, SD for C and D. Statistical significance was determined in relation to the tumor only sample by a two-tailed Student's T-test (*p < 0.05, **p < 0.01).