Table 3. Tumor genomic abnormalities as detected by tissue versus ctDNA NGS testing.

Pt	DNA repair		Cell cycle regulation		PI3K		Epigenetics		Angiogenesis
	Tissue	ctDNA	Tissue	ctDNA	Tissue	ctDNA	Tissue	ctDNA	Tissue	ctDNA
1	X		X	X	X		X
2	X		X	X	X		X		X	X
3	X		X				X
4			X	X			X
5			X			X
6	X		X	X
7				X	X		X
8	X						X		X
9	X				X		X
10	X		X
11	X		X		X
12	X			X	X				X	X
13			X		X				X	X
14	X					X	X
15									X
16	X		X
17	X		X	X			X		X
18			X						X	X
19					X		X		X
TOTAL	12	0	12	7	8	2	10	0	8	4
P VAL	0.0001		0.19		0.06		0.0004		0.30

Legend:

DNA repair includes: BAP1, POLE, FANCD2, EMSY, FANCF, POLD1, BARD1, PMS2, BRCA1, BRCA2, PALB2.

Cell cycle regulation: BTG1, CCND1, CCND2, CCND3, CDKN2A, CDKN2B, CCNE1, TP53.

PI3K: PREX2, RICTOR, PIK3CA, RPTOR, PTEN.

Epigenetics: MLL2, SETD2, DOT1L, CHD2, KDM6A, DNMT2A.

Angiogenesis: VHL, FLT4.

Genes tested by ctDNA are underlined. All genes were tested by tissue NGS.