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. 2017 Apr 6;8(20):33683–33693. doi: 10.18632/oncotarget.16898

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Copyright: © 2017 Wang et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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MTT assay showed that the viability of liver cancer cells was inhibited with the treatment of Raloxifene for 24 h in Hep-G2 (A), 7721 (B), and Huh-7 (C). However, Raloxifene did not significantly inhibit the cell viability of LO2, which is a normal hepatocyte cell line (D). Raloxifene inhibited colony formation in Huh-7 and 7721 liver cancer cells (E). Cells colony formation ability was investigated after treatment with Raloxifene for 4 h. The results showed that Raloxifene suppressed the proliferation and regeneration ability of Huh-7 and 7721 cancer cells. Raloxifene inhibited cell migration in Huh-7 cancer cells (F). With Raloxifene treatment for 4 h, wound-healing assay was used to test the migration ability of Huh-7 cancer cells. Raloxifene inhibited cell migration with the concentration of 50 and 75 μM.