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. 2017 Apr 4;8(20):33779–33795. doi: 10.18632/oncotarget.16810

Figure 9. SEL120-34A inhibits growth of AML tumors in a dose- dependent manner.

Figure 9

(A) Volume kinetic of KG-1 tumors and (B) MV4-11 tumors grown subcutaneously in SCID mice, treated orally with vehicle (water) or indicated doses of SEL120-34A once every day. Changes in animals’ body weights are shown in the inset; n=8, SD is shown. (C) Levels of total STAT1, STAT3 and STAT5 and phosphorylated STAT1 S726, Y701, STAT3 S727, Y705, STAT5 726, Y694 were analyzed in KG-1 tumors from control (vehicle) and SEL120-34A treated animals at day 23. (D) Levels of total on STAT5 and phosphorylated STAT5 S726, Y694, MCL-1, PARP and Cleaved PARP, total RNAPII and phosphorylated RNAPII CTD S2 were analyzed in MV4-11 tumors from control (vehicle) and SEL120-34A treated animals at day 17.