Table 2. Relationship between c amplification and the clinicopathologic features (n = 327).
| FGFR2 gCN of <8 | FGFR2 gCN of ≥8 | p | ||
|---|---|---|---|---|
| (n = 311, 95.1%) | (n = 16, 4.9%) | |||
| Age | Median (range) | 58 (23–85) | 50.5 (32–66) | |
| <65 years | 219 (70.4) | 15 (93.8) | 0.047 | |
| ≥65 years | 92 (29.6) | 1 (6.3) | ||
| Gender | Male | 216 (69.5) | 10 (62.5) | 0.584 |
| Female | 95 (30.5) | 6 (37.5) | ||
| ECOG PS | 0–1 | 277 (89.1) | 11 (68.8) | 0.031 |
| 2–4 | 34 (10.9) | 5 (31.3) | ||
| Bormann type | I/II/III | 257 (85.7) | 9 (56.3) | 0.006 |
| IV | 43 (14.3) | 7 (43.8) | ||
| Histology | WD/MD | 115 (37.7) | 2 (12.5) | 0.041 |
| PD/SRC/mucinous | 190 (62.3) | 14 (87.5) | ||
| Peritoneal metastasis | No | 164 (52.7) | 6 (37.5) | 0.234 |
| Yes | 147 (47.3) | 10 (62.5) | ||
| Liver metastasis | No | 218 (70.1) | 14 (87.5) | 0.166 |
| Yes | 93 (29.9) | 2 (12.5) | ||
| Lung metastasis | No | 292 (93.9) | 15 (93.8) | 1.0 |
| Yes | 19 (6.1) | 1 (6.3) | ||
| Intraabdominal distant LN metastasis | No | 163 (52.4) | 10 (62.5) | 0.43 |
| Yes | 148 (47.6) | 6 (37.5) | ||
| Extra-abdominal distant LN metastasis | No | 285 (91.6) | 11 (68.8) | 0.011 |
| Yes | 26 (8.4) | 5 (31.3) | ||
| Bone metastasis | No | 289 (92.9) | 11 (68.8) | 0.006 |
| Yes | 22 (7.1) | 5 (31.3) | ||
| Hemoglobina,b | >LNL | 89 (29.5) | 6 (37.5) | 0.576 |
| ≤LNL | 213 (70.5) | 10 (62.5) | ||
| White blood cell b | <10000/mm3 | 257 (85.1) | 14 (87.5) | 1.0 |
| ≥10000/mm3 | 45 (14.9) | 2 (12.5) | ||
| Platelet b | >150×103/mm3 | 268 (88.7) | 12 (75.0) | 0.11 |
| ≤150×103/mm3 | 34 (11.3) | 4 (25.0) | ||
| Albuminc | >3.3 g/dL | 202 (67.1) | 10 (66.7) | 1.0 |
| ≤3.3 g/dL | 99 (32.9) | 5 (33.3) | ||
| Alkaline phosphatase b | ≤120 IU/L | 235 (77.8) | 12 (75.0) | 1.0 |
| >120 IU/L | 67 (22.2) | 4 (25.0) | ||
| Total bilirubin b | ≤1.2 mg/dL | 274 (90.7) | 15 (93.8) | 1.0 |
| >1.2 mg/dL | 28 (9.3) | 1 (6.3) | ||
| Risk groups b,d | Good | 147 (48.7) | 7 (43.8) | 0.004 |
| Moderate | 110 (36.4) | 2 (12.5) | ||
| Poor | 45 (14.9) | 7 (43.8) |
Abbreviations: gCN, gene copy numbers; ECOG PS, Eastern Cooperative Oncology Group Performance Status; WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated; SRC, signet ring cell carcinoma; LN, lymph node; LNL, lower normal limit
aHemoglobin ≤12 g/dL for women and ≤13 g/dL for men.
bInitial complete blood count, alkaline phosphatase level, bilirubin level, and scores of the Asan Medical Center prognostic model were not available for 9 patients (2.8%).
cAlbumin levels were not available in 11 patients (3.4%)
dAccording to the Asan Medical Center prognostic model