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. 2017 Feb 16;8(20):33897–33910. doi: 10.18632/oncotarget.15406

Figure 1. Pathogenetic mechanisms of immune-tolerance in HCC.

Figure 1

Abbreviation - CAF: cancer associated fibroblast; CTLA4: cytotoxic T-limphocite antigen-4; HBV: hepatits B virus; HCV: hepatits C virus; h-SC: hepatic stellate cells; IDO: indoleamine 2,3 dioxygenase; IL: interleukin; LSEC: liver sinusoidal endothelial cells; MDSC: myeloid-derived suppressor cells; NK: natural killer; NKp30: natural killer protein 30; PD-1:programmed cell death protein 1; PD-L1: programmed cell death protein ligand 1; PG-E2: prostaglandin E2; TGF-β: transforming growth factor β; VEGF: vascular endothelial growth factor.