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. 2017 Mar 30;8(20):33990–34000. doi: 10.18632/oncotarget.16722

Table 2. Summary of meta-analysis results for BMI and bladder cancer risk.

Analysis specification Studies SRR (95%CI) I2 (%) P*
Overweight
All 14 1.03 (0.95-1.11) 30.4 0.133
Mean age
≥50 5 1.01 (0.43-1.21) 24.8 0.104
<50 7 0.94 (0.87-1.34) 0.0 0.419
Year of publication
≥2008 6 1.03 (0.89-1.09) 3.4 0.411
<2008 8 1.05 (0.78-1.28) 0.0 0.633
Follow-up duration
≥10 years 8 0.96 (0.57-1.23) 0.0 0.857
<10 years 6 1.07 (0.89-1.18) 16.2 0.153
Sample size
≥1,000,000 4 1.05 (0.45-1.37) 0.0 0.477
<1,000,000 10 1.01 (0.96-1.10) 54.6 0.031
Assessment of BMI
Measured 6 1.10 (0.91-1.23) 53.4 0.008
Self-reported 7 1.02 (1.86-1.15) 12.9 0.301
Geographic area
Asia 3 1.02 (0.97-1.08) 0 0.675
Europe 4 1.06 (0.97-1.73) 47.0 0.100
America 4 1.03 (0.79-1.34) 0.0 0.861
Multi–international centers 2 1.09 (0.98-1.56) 12.9 0.351
Physical activity
Yes 2 1.07 (0.94-1.29) 35.9 0.191
No 12 1.15 (1.00-1.98) 42.7 0.121
Family history of cancer
Yes 2 1.15(0.93–1.29) 12.8 0.543
No 12 1.06(1.00–1.19) 36.1 0.087
Obesity
All 14 1.10 (1.03-1.17) 58.5 0.003
Mean age
≥50 6 1.19 (1.08-1.22) 19.9 0.267
<50 6 1.01 (1.09-1.68) 56.8 0.061
Year of publication
≥2008 6 1.10 (1.53-1.89) 27.1 0.171
<2008 8 1.02 (1.14-1.40) 66.2 0.000
Follow-up duration
≥10 years 8 1.30 (1.02-1.39) 0.0 0.424
<10 years 6 1.07 (1.04-1.74) 10.3 0.231
Sample size
≥1,000,000 4 1.14 (1.01-1.61) 24.8 0.200
<1,000,000 10 1.04 (1.08-1.54) 37.1 0.112
Assessment of BMI
Measured 7 1.09(1.02–1.13) 12.5 0.354
Self-reported 6 1.24(1.09–1.40) 32.4 0.187
Geographic area
Europe 3 1.84 (1.55-2.19) 0.0 0.651
America 4 1.97 (1.40-2.75) 18.8 0.214
Asia 3 2.29 (1.46-3.58) 17.1 0.341
Smoking
Yes 2 1.11(1.05–2.16) 24.1 0.145
No 12 1.17(1.05–1.46) 8.81 0.653
Family history of cancer
Yes 2 1.13(1.07–1.19) 29.9 0.201
No 12 1.09(1.04–1.13) 1.83 0.412

BMI: Body mass index, SRR: The summary relative risk, *P value for heterogeneity.