Figure 7. Memory T cell changes in blood of anti-CD40 Ab-treated primates after transplantation.

(A–F) The changes of IFNγ⁺CD4⁺ or IFNγ⁺CD8⁺ T cells, effector (CD28⁻CD95⁺) memory CD4⁺ and CD8⁺ T cells, or central (CD28⁺CD95⁺) memory CD4⁺ and CD8⁺ T cells (black line) were not higher than those of preoperative states throughout the follow-up (baseline vs 6 months; p>0.05, Wilcoxon signed rank test; n=4) (G-K) The level of IFNγ⁺CD4⁺ or IFNγ⁺CD8⁺ T cells, effector/central memory CD4⁺ and effector memory CD8⁺ T cells were not different between anti-CD40 treated and anti-CD154 treated primates at baseline, at 1 month, and at 6 months after transplantation (p>0.05, Mann-Whitney U test). (L) The level of CD8⁺ central memory T cells was significantly lower in anti-CD 40 treated primates at 1 month after transplantation (p=0.0317, Mann-Whitney U test). CM indicates central memory and EM indicates effector memory.