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(left panel) Structure of compound 1 and KD values with different BD domains of BET members. (right panel) Overlap of cocrystal structures of 1 with BRD4 BD1 (yellow; PDB ID: 4MR4) and BRD2 BD2 (turquoise; PDB ID: 4MR6). The labeled residue is His433 (magenta) in the BRD2 BD2 domain and Asp144 (green) in the BRD4 BD1 domain.
