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(a) Domain organization of the long form of BRD4. (b) Conserved sequences of BRD4 BD1 and BRD4 BD2. The important critical residues that may contribute to the acetyl-lysine binding specificity are highlighted in different colors. (c) (left panel) Ribbon representation of BRD4 BD1 (PDB ID: 3UW9). (right panel) Surface representation of the KAc binding pocket of BRD4 BD1. Asn140 is highlighted in red, and the WPF shelf is highlighted in green.
