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. 2017 Feb 14;60(11):4533–4558. doi: 10.1021/acs.jmedchem.6b01761

Figure 6.

Figure 6

Discovery and development of BRD4 inhibitor 2. PBMC: peripheral blood mononuclear cells; BZDR: the central GABA receptor; t1/2, determined by an in vitro assay; T1/2, performed in vivo.