Table 1.
Curated list of active clinical drug trials for the prevention or treatment of sensorineural hearing loss. Source: Clinicaltrials.gov, as of July 9, 2016. DB – Double Blind, OL – Open Label. NIDCD - National Institute on Deafness and Other Communication Disorders.
| Trial Drug | First Listed Sponsor | Recruitment | Trial Phase | Funding | Masking | Start Date | End Date |
|---|---|---|---|---|---|---|---|
| PF-04958242 | Pfizer | Completed | Phase 1 | Industry | DB | Dec. 2011 | Feb. 2013 |
| SPI-1005 | Sound Pharmaceuticals Inc. | Completed | Phase 1 | Industry | DB | May 2006 | Aug. 2006 |
| HPN-07 | Otologic Pharmaceutics, Inc. | Completed | Phase 1 | Industry | DB | Oct. 2014 | Jan. 2015 |
| N-Acetylcysteine | Children’s Hospital Los Angeles | Recruiting | Phase 1 | Other | OL | Mar. 2016 | Feb. 2018 |
| Anakinra | Northwell Health | Completed | Phase 1 & 2 | Other | OL | Oct. 2013 | Jul. 2015 |
| Ancrod | Nordmark Arzneimittel GmbH & Co. KG | Recruiting | Phase 1 & 2 | Industry & Other | DB | May 2013 | Aug. 2016 |
| Zonisamide | Washington University School of Medicine | Not yet | Phase 1 & 2 | Other | OL | Jun. 2017 | Dec.2019 |
| Anakinra | NIDCD | Completed | Phase 1 & 2 | Other& NIH | OL | Jun. 2011 | Sept. 2014 |
| CGF166 | Novartis Pharmaceuticals | Recruiting | Phase 1 & 2 | Industry | OL | Oct. 2014 | Aug. 2017 |
| AUT00063 | Autifony Therapeutics Limited | Active, not recruiting | Phase 2 | Industry | DB | Jan. 2015 | Apr. 2016 |
| AM-111 | Auris Medical, Inc. | Completed | Phase 2 | Industry | DB | Dec.2008 | Jul. 2012 |
| N-acetylcysteine | National Taiwan University Hospital | Completed | Phase 2 | Other | DB | Nov. 2007 | Jan. 2008 |
| SPI-1005 | Sound Pharmaceuticals, Inc. | Not yet | Phase 2 | Industry & U.S. Federal | DB | Aug. 2016 | Jan. 2018 |
| SPI-1005 | Sound Pharmaceuticals, Inc. | Not yet | Phase 2 | Industry | DB | Sept. 2016 | Aug. 2017 |
| EPI-743 | Edison Pharmaceuticals Inc. | Completed | Phase 2 | Industry | DB | Oct. 2014 | Nov. 2015 |
| SPI-1005 | Sound Pharmaceuticals Inc | Completed | Phase 2 | Industry & Other | DB | Sept. 2011 | Dec. 2013 |
| Vestipitant | GlaxoSmithKline | Completed | Phase 2 | Industry | DB | Dec. 2006 | Aug. 2009 |
| N-acetylcysteine | TC Erciyes University | Completed | Phase 2 & 3 | Other | OL | Jun. 2010 | Nov. 2011 |
| Alpha-lipoic acid | VA Office of Research and Development | Completed | Phase 2 & 3 | U.S. Federal & Other | DB | Oct. 2007 | Mar. 2011 |
| Sodium thiosulfate | Children’s Oncology Group | Active, not recruiting | Phase 3 | Other & NIH | OL | Jun. 2008 | Sept. 2012 |
| AM-111 | Auris Medical, Inc. | Recruiting | Phase 3 | Industry | DB | Jun. 2016 | Jun. 2018 |
| D-methionine | Southern Illinois University | Recruiting | Phase 3 | U.S. Federal | DB | Sept. 2013 | Dec. 2016 |