Table 1.
sHSPs influence lifespan and human pathology. Summary of prominent examples where sHSP function has been associated with lifespan and manifestation of age-associated disease
| sHSPs | Organism | Ageing | Mutation | Pathology | References |
|---|---|---|---|---|---|
| HSP-16.48, HSP-43, HSP-17 and SIP-1 | C. elegans | Elevated, required for normal lifespan | – | – | (Hsu et al. 2003; Walther et al. 2015) |
| HSP22 | D. melanogaster | O/E prolongs lifespan | – | – | (Morrow et al. 2016) |
| Α-Crystallin(HSPB4-HSPB5 complex) | M. musculus, H. sapiens | – | R120G | Presbyopia, Cataracts | (Andley et al. 2011; Heys et al. 2007) |
| HSP22/HspB8 | M. musculus, H. sapiens | – | K141E K141N | Charcot–Marie-Tooth | (Irobi et al. 2004) |
| HSP27/HSPB1 | M. musculus, H. sapiens | – | R127W S135F R136W T151I P182L P182S |
Charcot–Marie-tooth | (Evgrafov et al. 2004) |
| HSP22/HspB8 | M. musculus, H. sapiens | – | K141N | Cardiomyopathy | (Sanbe et al. 2013) |
| HSP20/HSPB6 | M. musculus, H. sapiens | – | S16A S16D |
Cardiac disease | (Martin et al. 2014a; Qian et al. 2009) |
| αB-crystallin/HSPB5 | M. musculus, H. sapiens | – | R120G | Myopathy and heart failure | (Rajasekaran et al. 2007; Vicart et al. 1998) |
| HSPB7 | H. sapiens | – | SNP (rs1739843) | Dilated cardiomyopathy | (Stark et al. 2010) |
| HSP27/HSPB1 | M. musculus, H. sapiens | – | CVD and inflammation | (Batulan et al. 2016; Seibert et al. 2013) | |
| HSP27/HSPB1 | M. musculus, H. sapiens | – | Cancer development | (Acunzo et al. 2012; Arrigo and Gibert 2014) | |
| αA-crystallin/HSPB4, αB-crystallin/HSPB5 HSP22/HSPB8 | M. musculus, H. sapiens | – | Cancer development | (Acunzo et al. 2012; Arrigo and Gibert 2014) |