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. 2017 Jun 8;7:3059. doi: 10.1038/s41598-017-03259-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Release of ingredients from MPs in digestive conditions. (a) Time dependent release profile of encapsulated 100 nm FNPs (i) and SRB (ii) from MPs subjected to simulated GI tract environment (stomach: 2-hr incubation at pH 2.0 and 37 °C, and intestine: 4-hr incubation at pH 7.1 and 37 °C). (b), (c) Representative fluorescence micrographs of (b) FNP- and (c) SRB-encapsulating MPs after incubation at simulated gastric and intestinal conditions. As a control, fluorescent micrographs of MPs without FNP and SRB are shown for comparison.