Table 3. Blood and sputum biomarkers in controlled and uncontrolled asthma.
| Variables | Controlled asthma | Uncontrolled asthma | P value |
|---|---|---|---|
| Sputum cell count | |||
| Sputumb (N) | 146 | 90 | |
| Eosinophils (%) | 0.2 (0, 1.3) | 1.68 (0, 17.1) | <0.0001 |
| Neutrophils (%) | 8.75 (0.6, 39.25) | 3.85 (0.2, 32.25) | 0.215 |
| Macrophage (%) | 82.38 (55.0, 94.0) | 71.63 (34.2, 91.0) | 0.050 |
| Lymphocyte (%) | 0.95 (0.25, 2.300 | 0.88 (0.25, 1.900 | 0.619 |
| Sputum inflammatory phenotypec | <0.0001 | ||
| Eosinophilic | 25 (17.1%) | 38 (42.2%) | |
| Neutrophilic | 18 (12.3%) | 9 (10.0%) | |
| Paucigranulocytic | 102 (69.9%) | 41 (45.6%) | |
| Mixed | 1 (0.7%) | 2 (2.2%) | |
| Full blood countb (N) | 210 | 135 | |
| White cell count, ×109/L | 6.51 (5.30, 8.03) | 7.30 (6.0, 8.80) | 0.001 |
| Eosinophils, ×109/L | 0.20 (0.10, 0.34) | 0.25 (0.10, 0.50) | 0.052 |
| Monocytes, ×109/L | 0.39 (0.30, 0.50) | 0.47 (0.33, 0.60) | 0.0005 |
| Basophils, ×109/L | 0.03 (0.01, 0.04) | 0.02 (0, 0.07) | 0.507 |
| Lymphocytes, ×109/L | 1.85 (1.49, 2.26) | 2.19 (1.70, 2.70) | <0.0001 |
| Neutrophils, ×109/L | 3.79 (3.05, 5.02) | 4.11 (3.20, 5.30) | 0.101 |
| Platelets, ×109/L | 194.50 (155.0, 236.0) | 222.0 (177.0, 262.0) | 0.0003 |
| Red cell count, ×109/L | 4.68 (4.40, 5.06) | 4.83 (4.47, 5.20) | 0.056 |
| Serum biomarkers (N) | 135 | 43 | |
| Serum IgEb, IU/mL | 102.71 (36.26, 213.44) | 187.0 (43.52, 441.15) | 0.057 |
Data given as bmedian (Q1, Q2), cNo. (%), Italic face indicates significant.