Table 5. Characteristics of patients with severe and non-severe asthma.
| Variables | Non-severe asthma | Severe asthma | P value |
|---|---|---|---|
| N | 323 | 56 | |
| Agea | 47.20 (13.89) | 48.15 (14.39) | 0.639 |
| Male/Female | 142/181 | 21/35 | 0.367 |
| Smokingc: never | 183/296 (61.8) | 34/48 (70.8) | 0.099 |
| Pack years (ex/current smokers)b | 19.5 (7.5, 31.5) | 21.9 (7.1, 37.75) | 0.731 |
| Atopyc | 57/95 (60.0) | 21/32 (65.6) | 0.572 |
| Pre-β2 agonist spirometrya (N) | 321 | 54 | |
| FEV1% predicted | 70.73(23.24) | 75.92 (23.35) | 0.131 |
| FVC % predicted | 87.76 (20.71) | 91.85 (16.75) | 0.170 |
| FEV1/FVC | 66.23 (14.36) | 67.87 (14.58) | 0.463 |
| Post-β2 agonist spirometrya (N) | 293 | 47 | |
| FEV1% predicted | 78.38 (23.61) | 79.96 (22.79) | 0.669 |
| FVC % predicted | 93.84 (20.31) | 94.40 (15.17) | 0.859 |
| FEV1/FVC | 68.78 (14.10) | 69.55 (15.24) | 0.730 |
| Asthma control | |||
| Uncontrolled Asthma (ACQ score ≥1.5)c | 138/317 (43.5) | 9/56 (16.1) | <0.0001 |
| ACQ6 scoreb | 1.17 (0.5, 2.0) | 0.58 (0, 1.17) | <0.0001 |
| Exacerbation history | |||
| ≥1 severe exacerbation in past year requiring OCS | 111/321 (34.6) | 22/56 (39.3) | 0.496 |
| Hospital admission | 87/323 (26.9) | 26/56 (46.4) | 0.101 |
| ICU admission | 3/323 (0.9) | 0/56 | 1.000 |
| ER visit | 37/320 (11.6) | 10/55 (18.2) | 0.171 |
| Unscheduled doctor visit | 85/321 (26.5) | 18/56 (32.1) | 0.380 |
| Respiratory medications | |||
| OCS usec | 4/323 (1.2) | 2/56 (3.6) | 0.217 |
| ICS/LABA usec | 103/322 (32.0) | 56/56 (100.0) | <0.0001 |
| ICS dose (BDPmcg/day)b | 400 (200, 800) | 650 (400, 1,000) | 0.0002 |
| Long acting anticholinergicc | 7/323 (2.2) | 1/56 (1.8) | 1.0 |
| Leukotriene modifierc | 21/322 (6.5) | 49/56 (87.5) | <0.0001 |
| Theophyllinec | 14/323 (4.3) | 35/56 (62.5) | <0.0001 |
ACQ, Asthma Control Questionnaire; BDP, beclomethasone dipropionate; ER, emergency room; ICS, Inhaled corticosteroid; ICU, intensive care unit; LABA, long-acting beta2-agonist; OCS, oral corticosteroid. Data given as amean (SD), bmedian (Q1, Q2), cNo. (%). Italic face indicates significant.