Table 6. Blood and sputum biomarkers in severe and non-severe patients.
| Variables | Non-severe asthma | Severe asthma | P value |
|---|---|---|---|
| Sputum cell count | |||
| Sputumb (N) | 198 | 38 | |
| Eosinophils (%) | 0.6 (0, 4.5) | 0 (0, 0.75) | 0.026 |
| Neutrophils (%) | 4.4 (0.3, 35.75) | 13.25 (2.75, 36.75) | 0.069 |
| Macrophage (%) | 80.38 (46.50, 93.50) | 70.63 (51.25, 92.0) | 0.600 |
| Lymphocyte (%) | 1.0 (0.25, 2.50) | 0.5 (0.25, 1.30) | 0.320 |
| Sputum absolute cell countb (N) | N=148 | N=36 | |
| Eosinophils, ×104/mL | 0.24 (0, 4.59) | 0 (0, 0.27) | 0.020 |
| Neutrophils, ×104/mL | 3.53 (0.47, 13.89) | 7.68 (1.26, 16.40) | 0.197 |
| Macrophage, ×104/mL | 43.78 (18.96, 273.33) | 24.19 (16.98, 39.26) | 0.017 |
| Lymphocyte, ×104/mL | 0.8 (0.16, 5.39) | 0.32 (0.11, 0.67) | 0.022 |
| Sputum inflammatory phenotypec | 0.307 | ||
| Eosinophilic | 57 (28.8%) | 6 (15.8%) | |
| Neutrophilic | 23 (11.6%) | 4 (10.5%) | |
| Paucigranulocytic | 115 (58.1%) | 28 (73.7%) | |
| Mixed | 3 (1.5%) | 0 | |
| Full blood countb (N) | 296 | 53 | |
| White cell count, ×109/L | 7.0 (5.74, 8.50) | 6.10 (5.10, 7.85) | 0.025 |
| Eosinophilis, ×109/L | 0.20 (0.10, 0.40) | 0.17 (0.07, 0.31) | 0.036 |
| Monocytes, ×109/L | 0.40 (0.30, 0.52) | 0.35 (0.27, 0.60) | 0.184 |
| Basophils, ×109/L | 0.03 (0, 0.05) | 0.02 (0.01, 0.04) | 0.756 |
| Lymphocytes, ×109/L | 2.0 (1.64, 2.50) | 1.69 (1.32, 2.0) | 0.0001 |
| Neutrophils, ×109/L | 3.90 (3.12, 5.14) | 3.66 (3.12, 5.02) | 0.597 |
| Platelets, ×109/L | 210.5 (168.5, 252.5) | 169.0 (131.0, 220.0) | 0.0009 |
| Red cell count, ×109/L | 4.76 (4.43, 5.18) | 4.66 (4.37, 4.96) | 0.076 |
| Serum biomarkers (N) | 139 | 42 | |
| Serum IgEb, IU/mL | 116.45 (41.36, 303.49) | 95.48 (30.89, 306.37) | 0.612 |
Data given as bmedian (Q1, Q2), cNo. (%). Italic face indicates significant.