Figure 4.
Putative gene content of the euchromatic island in the pericentromeric region of the human Y. (A) The structure of the pericentromeric region of Yq11 is presented as a horizontal line with boxes representing segmental duplications. (B) Genomic properties of the Yq11 region: from top to bottom—(G+C) content, CpG islands, interspersed repeats including Alu, LINE, and HERV, satellite sequences including 5-bp and 68-bp repeats. (C) Only Y-specific sequences corresponding to exons of known autosomal genes or EST clusters with exon/intron boundaries are shown. Exons of the identified genes or pseudogenes identified are drawn to scale. For the ease of illustration, genic sequences were spread over four horizontal lines. (D) Large arrows indicate the predicted transcriptional direction. The GenBank accession nos. for sequences shown are Hs.252460, AF038169 (BC043584), FLJ42128 (AK124122), LOC339742 (BC045732), ASNS (NM_133436), FLJ39633 (AK096952), C21orf81 (AF426257), FLJ35140 (AK092459), FLJ00310 (AK090412), THC 1666755, DUX1 (NM_012146), PABPC1 (NM_002568), LOC150159 (NM_139173), ARP3β (NM_020445), FKSG74 (AY026352), CHEK2 (BC004207), TRIM43 (BC015353), and MGC32713 (BC034141). The state of each genic sequence is characterized as follows: Gene with intact ORF (7, 11-14, 17a);
EST cluster with unidentified ORF (1,10);
Partial gene (2, 9, 16, 18, 20);
Degenerated processed pseudogene (3, 4, 5, 6, 8, 15, 17, 19).