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. 2017 Jun 8;7:3052. doi: 10.1038/s41598-017-03164-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ymac-1 cell displays characteristics consistent with EMT. (A) Determination of N-cadherein (N-cad), E-cadherin (E-cad), Vimentin (Vim) mRNA expression in normal liver (N, n = 3), HCC tissues from Gnmt−/− mice (T, n = 4) and Ymac-1 cells (Y). Data is presented as mean ± s.d. *P < 0.05 and ***P < 0.001, using Student’s t-test. (B) Western blot of analyses of N-cad, Vim, and E-cad in normal liver (N, n = 4), HCC tissues from Gnmt−/− mice (T, n = 4) and Ymac-1 cells. (C) Representative picture and quantitative results of wound healing assay of Ymac-1 and Hepa1-6 cells. Bar: 100 μm. Data is presented as mean ± s.d. **P < 0.01, ***P < 0.001, using repeated measures ANOVA analysis with a Bonferroni post hoc test. (D) Anchorage-independent growth of Ymac-1 cell. Right panel is the quantitative results. Data is presented as mean ± s.d. ***P < 0.001, significant linear trend over dose levels.