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. 2005 Feb 1;19(3):397–410. doi: 10.1101/gad.330105

Figure 4.

Figure 4.

Abnormal lymphatic drainage in ephrinB2 mutant mice. (A-E) Visualization of the dermal lymphatic vessels using fluorescence microscopy after FITC-dextran injection into the forelimb footpad of wild-type mice (+/+) at P0 (A) and at P10 (B), and of ephrinB2 knock-in mutants at P10 (C-E). (A) At P0, the whole primitive dermal lymphatic vessel network is visualized after FITC-dextran injection. At P10, in wild-type (B) and knock-in control (C) mouse skin, only subcutaneous collecting lymphatic vessels (arrowheads) are visualized, while in ephrinB2ΔV/ΔV (D) and ephrinB25F/5F (E) mutant mice a vessel network is observed. Bars, 500 μm.