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. 2017 Jun 8;7:3032. doi: 10.1038/s41598-017-03321-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The stage-dependent sensitivity for each CRC stage with 1/3, 2/3, 1/2 or 1/1 algorithm. Panel A compares the sensitivity for each CRC stage at each algorithm. It is clear that the sensitivity increased with the elevation of stages, no matter what algorithm was applied. Panel B compares the sensitivity calculated from each algorithm at each CRC stage. Generally, 1/3 algorithm exhibited the highest sensitivity, followed by 2/3, 1/1 and 1/2 algorithms, no matter what stage was compared.