Figure 5.

Effects of cyclooxygenase (COX)-1 inhibitors on the COXs expression and NF-kB phosphorylation induced by lipopolysaccharide (LPS) in BV2 microglial cells. Total protein was subjected to SDS-PAGE, followed by immunoblotting using pIkBα antibody. The quantification of relative band intensities was expressed as relative density, after normalization against β-actin densitometry. Each bar represents the means ± SE of three independent experiments. BV2 microglial cells incubated with medium alone (control) or treated with LPS alone or in presence of the P6 and mofezolac (M) for 48 h. ^§§§p ≤ 0.001 vs control, ***p ≤ 0.001 vs LPS alone.