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. 2017 Jun 9;8:657. doi: 10.3389/fimmu.2017.00657

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Copyright © 2017 Wang, Shahzad, Li, Zhang, Zhang, Xu, Wan and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo tracking and tissue distribution of killer artificial antigen-presenting cells (KaAPCs). Grafted bm1 mice were injected via the tail vein with indocyanine green-encapsulated KaAPCs, anti-Fas-MPs, or Blank-MPs. Fluorescence images were then acquired using the Maestro in vivo imaging system at different time points. (A) Whole-body fluorescence images for in vivo tracking of KaAPCs and the control microparticles (MPs). (B) Distribution of KaAPCs and control MPs in the excised organs 2 h after injection as displayed by ex vivo imaging. (C) Few KaAPCs circulated into the location of alloskin graft at 2-, 4-, and 6-h time points, as analyzed by whole-body fluorescence imaging. (D) Wright’s staining for peripheral blood cells and spleen cells (SPCs). KaAPCs were observed in the blood cells suspension at 30-min time point and in the SPCs’ suspension at 1-h time point after i.v. injection in the KaAPCs group. Meanwhile, no KaAPC was found in the PBS injection group. White arrows point at the KaAPCs.