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. 2017 Jun 9;8:643. doi: 10.3389/fimmu.2017.00643

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Copyright © 2017 Donninelli, Del Cornò, Pierdominici, Scazzocchio, Varì, Varano, Pacella, Piconese, Barnaba, D’Archivio, Masella, Conti and Gessani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Obese (Ob) and colorectal cancer (CRC)-affected individuals exhibit normal frequencies of peripheral blood (PB) and visceral adipose tissue (VAT)-associated total γδ T lymphocytes but a significantly reduced Vγ9Vδ2/γδ T cell ratio in PB that correlates with body mass index (BMI). VAT stromal vascular fraction (SVF) and PB lymphocytes isolated from lean normal weight (Nw), Ob, lean affected by CRC (Nw/CC), and Ob affected by CRC (Ob/CC) donors were analyzed by flow cytometry. Frequency of total γδ T cells (among CD3⁺ T cells) was evaluated in SVF (A) and PB (B). (C) Vγ9Vδ2/γδ T cell ratios (PB) were calculated in the four categories of donors. Each dot represents an individual donor. Mean ± SEM is shown for each group. ***p < 0.001, by analysis of variance. (D) Pearson’s correlation (r) between the Vγ9Vδ2/γδ T cell ratio and BMI in Nw and Ob subjects (**p < 0.01).