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. 2017 Jun 9;8:643. doi: 10.3389/fimmu.2017.00643

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Copyright © 2017 Donninelli, Del Cornò, Pierdominici, Scazzocchio, Varì, Varano, Pacella, Piconese, Barnaba, D’Archivio, Masella, Conti and Gessani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inverse distribution between total visceral adipose tissue (VAT) stromal vascular fraction (SVF) regulatory T (T_reg) and NKT-like cells and correlation with VAT polyunsaturated fatty acid content. Pearson’s correlation between: total T_reg and NKT-like cell frequencies in VAT SVF (A), arachidonic acid (AA) content, evaluated in visceral adipocytes, and T_reg cell frequency estimated in VAT SVF isolated from lean normal weight (Nw) and obese (Ob) donors (B), and docosahexaenoic (DHA) (C) and eicosapentaenoic acid (EPA) (D) content, evaluated in visceral adipocytes, and NKT cell frequency estimated in VAT SVF isolated from lean (Nw), lean affected by colorectal cancer (CRC) (Nw/CC) and Ob affected by CRC (Ob/CC) donors.