FIGURE 4.

Hyaluronidase infusion increased glycocalyx thickness in sham and blasted rats. Schema representing experimental design for experiment 2 (A). Each arrow represents an individual blast overpressure exposure (BOP) with red arrows denoting days with hyaluronidase infusion. Representative electron micrographs of capillaries from cerebral cortex taken from blast and sham blasted animals infused with hyaluronidase or vehicle. Capillaries from hyaluronidase infused sham controls (C) and blast exposed (E) rats had qualitatively thicker glycocalyx when compared to saline infused sham controls (B) or blast exposed (D) animals. All insets represent magnified image; scale bar = 500 nm.