Figure 1.

Molecular structure of TRPA1 and TRPV1. (A) Scheme of TRPV1 and TRPA1 channels depicting individual domains. Numbers correspond to amino acids positions of human TRPV1 and TRPA1, respectively. (B) Cartoon representing TRPV1 and TRPA1 monomers morphology within a bilayer membrane. The channel spans the membrane up to six times with the pore located between transmembrane domains (TM) 5 and 6, and both N-terminal and C-terminal domains situated in the cytosol. (C,D) Cartoons depicting the tetrameric assembly of TRPV1 subunits based on the X-ray crystal structure of Rattus norvegicus as described in Cao et al. (2013). As mentioned above, the ion permeation pathway is formed by TM5 and TM6, while the remaining TM domains 1–4, surround the pore. (C) Represents a frontal view of the channel while (D) sketches an upside-down perspective.