Table 1.

Agonists and antagonists of TRPV1 and TRPA1 channels.

Channel	Agonist	Potency (EC50)	Antagonist	Potency (IC50)	References
TRPV1	Capsaicin	0.04–1 μM	Agatoxin 489	0.3 μM	Jung et al., 2001; Behrendt et al., 2004; Varga et al., 2005; Rami et al., 2006; Harteneck et al., 2011; Planells-Cases et al., 2011; Vetter and Lewis, 2011; Xia et al., 2011
	Eugenol	1 mM	Agatoxin 505	0.3 μM
	Resiniferatoxin	39 nM	APHC1	54 nM
	Polygodial	5 μM	Capsazepine	420 nM
	Cinnamodial	0.6 μM	Nicotine	1 mM
	Isovelleral	100 nM	Yohimbine	25 μM
	Cannabidiol	3 μM	Acetylsalicylic acid	1 μM
	Ginsenoside Rc	?	Grifolin	26 μM
	VaTx1	12 μM	Neogrifolin	7 μM
	VaTx2	3 μM	Albaconol	17 μM
	VaTx3	0.3 μM	BCTC	35 nM
	Leukotriene B4	30 μM	AMG-517	32 nM
	12-S-HPETE	10 μM	SB366791	651 nM
	Anandamide	30 μM
TRPA1	Allyl isothiocyanate	1–6.5 μM	Camphor	0.6 mM	Karashima et al., 2007; Trevisani et al., 2007; Cruz-Orengo et al., 2008; Eid et al., 2008; Sculptoreanu et al., 2010; Harteneck et al., 2011; Vetter and Lewis, 2011; Trevisan et al., 2014; Wei et al., 2009; McGaraughty et al., 2010; Brenneis et al., 2011; Sisignano et al., 2012
	Cinnamaldehide	60μM	HC-030031	6.2 μM
	Methyl salicylate	600 μM	A-967079	67 nM
	Allicin	7.5 μM	Chembridge-5861528	?
	Ajoene	0.5 μM
	Diallyl trisufphide	0.5 μM
	Hydroxy-α-sanshool	69 μM
	Acrolein	5 μM
	Crotonaldehyde	16 μM
	Δ9 tetra-hydrocannabinol	12 μM
	Cannabinol	20 μM
	Hydrogen peroxide	?
	Nitrooleic acid	?
	4-hydroxy-2-nonenal	27 μM
	15-deoxy- Δ12,14-PGJ2	?
	5,6-EET	?
	8,9-EET	?
		?