Table 1.

Input parameters used in the pharmacology–epidemiology modules

Descriptor	Value
Population size (In)	100 000 cases
Latency period (1/κ)	1 day
FAUChigh (150 mg BID)	0.795 (0.095)
FAUChigh (75 mg BID)	0.326 (0.048)
Tshed(0) (No treatment)	6 (2.5) days
Tshed(low) (AUC 0–14 180 ng.h ml−1)	3 (0.58) days
Tshed(high) (AUC > 14 180 ng.h ml−1)	1.9 (0.51) days
β, Moderate infectivity	0.21 days−1
β, High infectivity	0.41 days−1

κ, the delay rate between exposure to influenza and symptom development; F_AUChigh, the mean (SD) fraction of the simulated population receiving oseltamivir with an AUC >14 180 ng.h ml⁻¹; T_shed(0), the duration of viral shedding under no treatment; T_shed(low), the mean (SD) duration of viral shedding if OC AUC is <14 180 ng.h ml⁻¹; T_shed(high), the mean (SD) duration of viral shedding if OC AUC is greater than 14 180 ng.h ml⁻¹ β, the rate of infectivity; AUC, area under the concentration–time curve; BID, twice daily