Table 1.
Summary of demographics and covariates
| Characteristic | Placebo group | 90 mg RBP‐7000 group | 120 mg RBP‐7000 group |
|---|---|---|---|
| Total number (n) | 112 | 111 | 114 |
| Age (years) | 42.76 ± 8.65 | 40.45 ± 9.42 | 40.41 ± 9.42 |
| Body weight (kg) | 92.61 ± 22.86 | 90.89 ± 18.86 | 88.54 ± 20.34 |
| Body mass index (kg m −2 ) | 30.97 ± 7.29 | 29.59 ± 5.96 | 29.33 ± 6.73 |
| Waist‐to‐hip‐ratio | 0.95 ± 0.09 | 0.95 ± 0.08 | 0.94 ± 0.07 |
| Alanine transferase (ALT, U/L) | 29.06 ± 20.09 | 29.88 ± 21.01 | 28.54 ± 23.58 |
| Aspartate transferase (AST, U/L) | 21.65 ± 8.5 | 23.14 ± 12.13 | 20.99 ± 8.66 |
| Creatinine clearance (CRCL, ml min −1 ) | 122.69 ± 46.91 | 121.91 ± 32.68 | 122.62 ± 39.77 |
| Gender (% male) | 81 (72.3) | 93 (83.78) | 84 (73.6) |
| Ethnicity | |||
| Not Hispanic or Latino | 101 (90.1%) | 104 (93.6%) | 104 (91.2%) |
| Other | 11 (9.8%) | 7 (6.3%) | 10 (8.7%) |
| Race | |||
| Black or African American | 84 (75%) | 79 (71.1%) | 80 (70.1%) |
| Other | 28 (25%) | 32 (28.8%) | 34 (29.8%) |
| CYP2D6 genotype metabolizer | |||
| Extensive | 92 (82.1%) | 98 (88.2%) | 97 (85.0%) |
| Intermediate | 8 (7.1%) | 4 (3.6%) | 7 (6.1%) |
| Poor | 3 (2.6%) | 1 (0.9%) | 3 (2.6%) |
| Inconclusive | 8 (7.1%) | 7 (6.3%) | 6 (5.2%) |
| Missing | 1 (0.9%) | 1 (0.9%) | 1 (0.8%) |
| Dopamine D2 receptor (DRD2) genotype (rs1801028) | |||
| GG | 106 (94.6%) | 108 (97.2%) | 113 (99.1%) |
| GC | 5 (4.4%) | 2 (1.8%) | 0 (0%) |
| Missing | 1 (0.9%) | 1 (0.9%) | 1 (0.9) |
| Serotonin 2C receptor (5‐HT2C) genotype (rs3813929) | |||
| CC | 102 (91.0%) | 102 (91.9%) | 104 (91.2%) |
| CT | 4 (3.6%) | 4 (3.6%) | 3 (2.6%) |
| TT | 5 (4.4%) | 4 (3.6%) | 6 (5.2%) |
| Missing | 1 (0.9%) | 1 (0.9%) | 1 (0.9%) |
| Serotonin 2A receptor (5‐HT2A) genotype (rs6313) | |||
| CC | 44 (39.2%) | 45 (40.5%) | 43 (37.7%) |
| CT | 55 (49.1%) | 49 (44.1%) | 48 (42.1%) |
| TT | 12 (10.7%) | 15 (13.5%) | 22 (19.2%) |
| Inconclusive | 0 (0%) | 1 (0.9%) | 0 (0%) |
| Missing | 1 (0.9%) | 1 (0.9%) | 1 (0.9%) |
| Melanocortin 4 receptor (MCR4) genotype (rs17782313) | |||
| CC | 9 (8.0%) | 9 (8.1%) | 11.4 (85.0%) |
| TC | 48 (42.8%) | 55 (49.5%) | 27.1 (6.1%) |
| TT | 54 (48.2%) | 46 (41.4%) | 60.5 (2.6%) |
| Missing | 1 (0.9%) | 1 (0.9%) | 1 (0.9%) |