Table 2.

Non‐parametric bootstrap‐based parameter estimates of the base and final covariate pharmacokinetic model for RBP‐7000

Parameter	Description	Estimate [95% CI]	BSV [95% CI] (%Shrinkage)
ka1	Rapid abs (h−1)	0.005 [0.004, 0.007]	41.8 [35, 50.7] (25.4)
ka2	Slow abs (h−1)	0.016 [0.01, 0.022]	32.1 [0.3, 49.9] (65.6)
krel	Elimination (h−1)	0.04 [0.03, 0.07]	—
V	App. vol of risp (l)	129.0 [96.0, 158.0]	38.6 [32.4, 44.8] (17.5)
ktr	Transit rate constants (h−1)	0.023 [0.021, 0.025]	42.3 [31.8, 52.7] (15.8)
krrp	Cen to Per (h−1)	0.84 [0.65, 1.14]	45.1 [28.4, 57.1] (36.3)
krpr	Per to Cen (h−1)	0.006 [0.005, 0.008]	67.9 [47.9, 81.3] (21.8)
kr9	Met formation (h−1)	0.22 [0.18, 0.28]	49.3 [37.8, 60.1] (8.8)
k9el	Met elimination (h−1)	0.07 [0.06, 0.09]	18.8 [0.2, 29.5] (52.6)
σadd	Additive RUV (ng ml−1)	0.13 [0.003, 0.214]
σprop	Proportional RUV	0.29 [0.27, 0.32]
CYP2D6 Intermediate	Effect on metabolite formation	−0.76 [−0.85, −0.56]
CYP2D6 Poor	Effect on metabolite formation	−0.94 [−0.96, −0.88]