Table A1.

Listing of Explored PANSS Placebo Models

Run	Reference	Description	Formula	OFV	dOFV
99		Baseline	BSL	3147.75
100	99	Linear Slope	BSL + α · TIME	2900.39	−247.36
101	100	Linear + Power	BSL + α · TIME POW	2846.22	−54.16
102	99	Exponential	$\mathit{\text{BSL}}-\mathit{\text{MDS}}·\left[1,-,e^{-k·T}\right]$	2840.45	−307.29
103	99	Weibull	$\mathit{\text{BSL}}·\left(1-\mathit{\text{MDS}}\times \left(1,-,{\text{exp}}^{{\left(-,\frac{T}{\mathit{\text{TPROG}}}\right)}^{\mathit{\text{POW}}}}\right)\right.$	2839.57	−308.181
104	103	Weibull + Linear	$\mathit{\text{BSL}}·\left(1-\mathit{\text{MDS}}\times \left(1,-,{\text{exp}}^{{\left(-,\frac{T}{\mathit{\text{TPROG}}}\right)}^{\mathit{\text{POW}}}}\right)+\mathit{\text{DRIFT}}*T\right.$	2823.958	−15.61