Table A2.

Comparison of PK parameter estimates across the three studies

Parameter	Description	Phase‐3		Pooled SAD & MAD
		Estimate	IIV %	Estimate	IIV %
ka1	Rapid abs (h−1)	0.005	42	0.0151	44
ka2	Slow abs (h−1)	0.016	32	0.0513	43
krel	Elimination (h−1)	0.043	‐	0.0092	91
V	Apparent Volume (L)	129	39	125	27
ktr	Transit Rate Constants (h−1)	0.023	42	0.0283	46
krrp	Cen to Per (h−1)	0.841	45	0.537	57
krpr	Per to Cen (h−1)	0.006	68	0.0226	59
kr9	Met Formation (h−1)	0.221	49	0.0474	66
K9el	Met Elimination (h−1)	0.069	19	0.062	27
σadd	Additive RUV (ng ml−1)	0.137		0.077
σprop	Proportional RUV (%)	29.7		33.5
	CYP2D6 IM ‐ Met Formation	‐0.76
	CYP2D6 PM ‐ Met Formation	‐0.942