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. 2005 Feb;15(2):330–340. doi: 10.1101/gr.2821705

Table 3.

Performance of aligners on the PREFAB protein reference alignment benchmark

Aligner Overall (1927) Time
DIALIGN 57.2 12 h, 25 min
CLUSTALW 58.9 2 h, 57 min
T-Coffee 63.6 144 h, 51 min
MUSCLE 64.8 3 h, 11 min
MAFFT 64.8 2 h, 36 min
ProbCons 66.9 19 h, 41 min
ProbCons-ext 68.0 37 h, 46 min

Entries show the average Q (equivalent to SP) score achieved by each aligner on all 1927 alignments of the PREFAB database. All scores have been multiplied by 100. Running times for programs over the entire database are given for each program in hours and minutes. The best results in each column are shown in bold.