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. 2017 Jun 5;8:15740. doi: 10.1038/ncomms15740

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The number of challenges required for detection of productive infection for each vaccine group. Kaplan–Meier plot indicates the percent of uninfected animals after each challenge. Ad/Env (blue) indicates animals primed with Ad35/Ad26 and boosted with adjuvanted Env gp140 (Ad35/Ad26/Env). Ad/Ad (red) indicates animals vaccinated with Ad35/Ad26 only. The RLD challenge study (a) shows infections over time with protection in 75% of Ad/Ad vaccinated animals and 85% of Ad/Env vaccinated animals. The SHD challenge study (b) shows infections in all control animals and protection in 20% of Ad/Ad vaccinated animals and in 40% protection in Ad/Env vaccinated animals.