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. 2017 Jun 5;8:15740. doi: 10.1038/ncomms15740

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The total number of T/F genomes was determined in each animal in the RLD (a) and SHD (b) challenge studies. Average and standard error are indicated. Significant differences in mean number of variants by Wilcoxon rank-sum tests are shown. Ad/Env (blue) indicates animals primed with Ad35/Ad26 and boosted with adjuvanted Env gp140 (Ad35/Ad26/Env). Ad/Ad (red) indicates animals vaccinated with Ad35/Ad26 only. Difference between vaccinated groups were not significant (n.s.).