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. 2017 Jun 5;8:15740. doi: 10.1038/ncomms15740

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Neutralizing antibody responses are shown at week 0 (a,c) and week 52 (b,d) in the vaccinated animals against both the non-AK neutralization-sensitive tier 1 SIVsmE660 clone (CP3C-P-A8) and the AK neutralization-resistant tier 2 SIVsmE660 clone (CR54-PK-2A5). IC₅₀ titres are reported for CP3C-P-A8. % neutralization values are reported for CR54-PK-2A5. Wilcoxon rank-sum tests were utilized to compare neutralizing antibody titres in protected versus infected vaccinated animals at week 52. Red line indicates median responses.