Table 1. Protective efficacy of Ad35/Ad26/Env and Ad35/Ad26 vaccines against RLD and SHD SIVsmE660 challenges.
| Challenge | Vaccine | Complete protection* | P value versus Sham | Hazard ratio (95% confidence interval) | Per-exposure risk reduction |
|---|---|---|---|---|---|
| Repetitive low-dose (RLD) | Ad35/Ad26/Env | 83% | 0.006† | 0.114 (0.024–0.541) | 88.6% |
| Ad35/Ad26 | 75% | 0.016† | 0.194 (0.051–0.072) | 80.6% | |
| Sham | 16% | N/A | 1 | N/A | |
| Single high-dose (SHD) | Ad35/Ad26/Env | 40% | 0.043‡ | N/A | N/A |
| Ad35/Ad26 | 20% | 0.237‡ | N/A | N/A | |
| Sham | 0% | N/A | N/A | N/A |
*Percent uninfected animals after 12 intrarectal challenges.
†Cox proportional hazard model.
‡Fisher's exact test.