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. 2017 Jun 5;8:15740. doi: 10.1038/ncomms15740

Table 1. Protective efficacy of Ad35/Ad26/Env and Ad35/Ad26 vaccines against RLD and SHD SIVsmE660 challenges.

Challenge Vaccine Complete protection* P value versus Sham Hazard ratio (95% confidence interval) Per-exposure risk reduction
Repetitive low-dose (RLD) Ad35/Ad26/Env 83% 0.006 0.114 (0.024–0.541) 88.6%
  Ad35/Ad26 75% 0.016 0.194 (0.051–0.072) 80.6%
  Sham 16% N/A 1 N/A
           
Single high-dose (SHD) Ad35/Ad26/Env 40% 0.043 N/A N/A
  Ad35/Ad26 20% 0.237 N/A N/A
  Sham 0% N/A N/A N/A

*Percent uninfected animals after 12 intrarectal challenges.

Cox proportional hazard model.

Fisher's exact test.