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. 2017 Jun 8;14:13. doi: 10.1186/s12950-017-0161-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — TMP relieved mechanical allodynia in periorbital region in CCI mice. Controlled cortical impact (CCI) was performed on the surface of the somatosensory cortex in the right hemisphere. Periorbital thresholds in both ipsilateral (a) and (b) contralateral sides were measured with von Frey filament assay. Sham (solid circle), CCI (solid square) and CCI + 4 mM TMP (open circle) mice. n = 6 in each group. Data are presented as mean ± SEM values and representative of at least three independent experiments. * P < 0.05; ** P < 0.01, compared with CCI mice