Table 2.

CpGs associated with CPO compared to CLO in the single-site EWAS analysis after filtering out age-related CpGs

Chr	CpG	Regression coefficient	P value	Gene	Relation to CpG island	Relation to gene
19	cg01634146	0.19	9.80 × 10−13	NFIX	S_Shelf	Body
22	cg12899065	0.16	3.98 × 10−8	GP1BB;SEPT5	Island	TSS1500;3′UTR
6	cg14623715	0.14	2.46 × 10−10	PDE7B		Body
10	cg02017450	−0.14	5.93 × 10−11	intergenic [SFTA1P]
8	cg04364695	−0.13	4.27 × 10−8	ZMAT4		Body
7	cg22114489	−0.13	4.60 × 10−8	intergenic [CUX2]
1	cg12697139	−0.13	2.23 × 10−11	intergenic [MIR205HG]
2	cg19075787	−0.13	8.44 × 10−9	intergenic [LOC284998]
11	cg17696044	−0.13	8.61 × 10−8	SHANK2		Body
20	cg19592472	−0.12	5.04 × 10−8	OXT	Island	1stExon;5′UTR
4	cg14348967	−0.12	5.12 × 10−9	intergenic [DQ599898]
6	cg00257775	−0.12	9.45 × 10−10	ZFAND3		Body
3	cg25938530	−0.11	2.04 × 10−8	ITIH1		TSS200;Body
11	cg12155547	−0.11	9.96 × 10−12	intergenic [NEAT1]	S_Shelf
1	cg18147098	0.11	5.44 × 10−8	intergenic [ATF3]	S_Shore
8	cg19496364	0.10	1.16 × 10−8	intergenic [LINC00535]
7	cg27508620	0.10	3.67 × 10−8	intergenic [SP4]
6	cg25426302	0.10	9.90 × 10−8	PPT2;PRRT1	N_Shore	TSS1500
10	cg20327845	−0.10	6.66 × 10−8	PFKP		Body
3	cg05581878	−0.10	2.50 × 10−9	intergenic [AK097161]
10	cg19220719	−0.10	7.02 × 10−9	intergenic [C10orf11]
22	cg13251842	0.09	6.67 × 10−8	MIRLET7A3;MIRLET7B		TSS200; TSS1500
19	cg27392771	0.09	5.25 × 10−15	NFIX	S_Shore	Body
6	cg23279756	−0.09	7.14 × 10−8	intergenic [ARMC2]
2	cg07644939	0.09	3.12 × 10−10	SNED1	S_Shore	Body

The top 25 CpGs with the largest effect sizes and P values <1 × 10⁻⁷ are shown. For intergenic regions, the closest annotated gene is shown in square brackets

S_Shore South shore, S_Shelf South shelf, N_Shore North shore, TSS1500 1500 base pairs from a transcription start site; TSS200 200 base pairs from a transcription start site, UTR untranslated region