Table 1.
The top 15 significantly enriched pathways for differentially expressed genes in T2D
| KEGG ID | KEGG term | Count | FDR | Genes |
|---|---|---|---|---|
| hsa05012 | Parkinson's disease | 10 | 1.33E-03 | NDUFA5,ATP5J,NDUFV2,SNCA,NDUFA12,LRRK2,ATP5C1,UQCRB,VDAC3,UBB |
| hsa03010 | Ribosome | 8 | 1.41E-03 | RPS3A,UBA52,RSL24D1,RPL7,RPL39,RPL21,RPS24,RPS12 |
| hsa05200 | Pathways in cancer | 13 | 1.26E-02 | PTCH1,FOS,BCL2L1,COL4A2,PTEN,BIRC3,TCF7,TCEB1,IL8,SMAD3,ITGB1,STK36,FN1 |
| hsa05222 | Small cell lung cancer | 6 | 1.48E-02 | BCL2L1,COL4A2,PTEN,BIRC3,ITGB1,FN1 |
| hsa05016 | Huntington’s disease | 9 | 1.49E-02 | NDUFA5,ATP5J,NDUFV2,NDUFA12,CREB5,ATP5C1,UQCRB,SP1,VDAC3 |
| hsa04210 | Apoptosis | 6 | 1.50E-02 | BCL2L1,BIRC3,IRAK3,DFFB,IL3RA,PRKACB |
| hsa05160 | Hepatitis C | 8 | 1.53E-02 | STAT2,TBK1,IL8,MAVS,OAS3,OAS1,NR1H3,EIF3E |
| hsa04640 | Hematopoietic cell lineage | 6 | 1.56E-02 | CD55,IL1R2,IL6R,TFRC,CD5,IL3RA |
| hsa04510 | Focal adhesion | 10 | 1.57E-02 | COL4A2,PTEN,MYL12B,BIRC3,RAP1B,ARHGAP5,ITGB1,MYL12A,FN1,PPP1CC |
| hsa04114 | Oocyte meiosis | 7 | 1.67E-02 | PPP2R5A,CDC27,SKP1,SLK,SMC3,PRKACB,PPP1CC |
| hsa04110 | Cell cycle | 7 | 1.76E-02 | ORC3,CDC27,ORC4,SKP1,DBF4,SMAD3,SMC3 |
| hsa03050 | Proteasome | 4 | 2.40E-02 | PSMC6,POMP,PSMD12,PSMA4 |
| hsa04120 | Ubiquitin mediated proteolysis | 7 | 2.54E-02 | CDC34,CDC27,BIRC3,UBE2W,TCEB1,SKP1,CUL3 |
| hsa04622 | RIG-I-like receptor signaling pathway | 5 | 2.56E-02 | TBK1,ATG5,TANK,IL8,MAVS |
| hsa03013 | RNA transport | 7 | 3.28E-02 | RANBP2,SRRM1,THOC7,NUP54,XPO1,POM121C,EIF3E |