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. 2017 May 1;292(23):9760–9773. doi: 10.1074/jbc.M117.783605

Figure 2.

Figure 2.

Manganese levels are elevated in 6-week-old Slc30a10 knock-out mice. A–D, Slc30a10+/+, Slc30a10+/−, and Slc30a10−/− mice were euthanized at 6 weeks of age. Samples of brain, liver, and blood were collected and used to measure absolute levels of manganese, zinc, copper, and iron (n = 8 males (M) and 4 females (F) for +/+, 7 males and 7 females for +/−, and 7 males and 5 females for −/− genotypes; the same animals were used to analyze all four metals; *, p < 0.05 for the difference between −/− and other genotypes for indicated measurements using two-way ANOVA and Sidak's post hoc test, irrespective of sex (main column effect); there were no differences between +/+ and +/− genotypes for any metal in any tissue; small, but statistically significant (p < 0.05 by two-way ANOVA and Sidak's post hoc test), sex-specific differences were seen in liver manganese, blood manganese, liver copper, and blood iron in Slc30a10−/− mice and in brain zinc and liver copper in Slc30a10+/− mice).