Table 1.
Characteristics of participating girls, by pubertal outcomes; the LEGACY Girls Study
| Category | Entire cohort (n = 1040) | Breast Tanner, girls aged <13 (n = 801) | Pubic hair Tanner, girls aged <13 (n = 835) | Menarche, girls ≥10 (n = 506) | |||
|---|---|---|---|---|---|---|---|
| Stage T1 (n = 506) |
Stage T2+ (n = 295) |
Stage T1 (n = 556) |
Stage T2+ (n = 279) |
No menses (n = 313) |
Menses (n = 193) |
||
| Continuous variables, mean (SD) | |||||||
| Age (years) | 10.1 (2.4) | 8.7 (1.7) | 11.2 (1.3) | 8.7 (1.7) | 11.2 (1.4) | 11.4 (1.0) | 13.2 (1.2) |
| Weight (kg) | 37.8 (14.6) | 29.6 (8.4) | 46.0 (12.4) | 30.1 (9.4) | 44.7 (13.2) | 41.1 (10.8) | 55.5 (13.1) |
| Height (cm) | 142.6 (15.3) | 133.5 (11.0) | 151.8 (10.7) | 133.4 (11.1) | 151.2 (11.1) | 149.9 (9.2) | 161.2 (7.5) |
| BMI (kg/m2) | 18.0 (4.3) | 16.4 (3.4) | 19.8 (4.3) | 16.7 (3.7) | 19.3 (4.3) | 18.2 (3.8) | 21.3 (4.3) |
| Maternal age at menarche | 12.7 (1.5) | 12.9 (1.5) | 12.4 (1.5) | 12.8 (1.5) | 12.6 (1.5) | 12.9 (1.5) | 12.4 (1.5) |
| Maternal age at daughter’s birth | 32.3 (5.5) | 32.6 (5.4) | 31.8 (5.7) | 32.5 (5.4) | 32.0 (5.7) | 32.4 (5.2) | 31.2 (5.8) |
| Categorical variables, count (%) | |||||||
| Overweight | |||||||
| ≥ 85th percentile | 193 (18.6) | 60 (11.9) | 90 (30.5) | 81 (14.6) | 71 (25.5) | 46 (14.7) | 55 (28.5) |
| Race/ethnicity | |||||||
| Hispanic | 193 (18.6) | 79 (15.6) | 60 (20.3) | 88 (15.8) | 60 (21.5) | 44 (14.1) | 58 (30.1) |
| Black | 78 (7.5) | 27 (5.3) | 34 (11.5) | 27 (4.9) | 36 (12.9) | 22 (7.0) | 17 (8.8) |
| Non-hispanic white | 646 (62.1) | 343 (67.8) | 172 (58.3) | 371 (66.7) | 160 (57.4) | 209 (66.8) | 91 (47.2) |
| Asian | 93 (8.9) | 46 (9.1) | 19 (6.4) | 55 (9.9) | 16 (5.7) | 31 (9.9) | 19 (9.4) |
| Mixed race/ethnicity | 30 (2.9) | 11 (2.2) | 10 (3.4) | 15 (2.7) | 7 (2.5) | 7 (2.2) | 8 (4.2) |
| Study site | |||||||
| Philadelphia | 154 (14.8) | 72 (14.2) | 53 (18.0) | 74 (13.3) | 52 (18.6) | 63 (20.1) | 25 (13.0) |
| Utah | 164 (15.8) | 86 (17.0) | 32 (10.9) | 100 (18.0) | 30 (10.8) | 45 (14.4) | 16 (8.3) |
| New York | 168 (16.2) | 95 (18.8) | 45 (15.2) | 102 (18.4) | 38 (13.6) | 39 (12.5) | 28 (14.5) |
| Ontario, Canada | 192 (18.5) | 103 (20.4) | 53 (18.0) | 113 (20.3) | 49 (17.6) | 53 (16.9) | 37 (19.2) |
| San Francisco Bay Area | 362 (34.8) | 150 (29.6) | 112 (38.0) | 167 (30.0) | 110 (39.4) | 113 (36.1) | 87 (45.1) |
| Maternal education | |||||||
| Some college/vocational/technical school or less | 284 (27.3) | 114 (22.5) | 101 (35.1) | 139 (25.0) | 85 (30.5) | 77 (24.6) | 73 (37.8) |
| Bachelor’s degree | 377 (36.3) | 194 (38.3) | 85 (29.5) | 210 (37.8) | 90 (32.3) | 107 (34.2) | 62 (32.1) |
| Graduate degree | 353 (33.9) | 191 (37.8) | 102 (35.4) | 199 (35.8) | 98 (35.1) | 124 (39.6) | 45 (23.3) |
| Breast cancer family history (BCFH) | |||||||
| No BCFH | 497 (47.8) | 267 (52.7) | 142 (48.1) | 277 (49.8) | 146 (52.3) | 154 (49.2) | 84 (43.5) |
| Any BCFH | 533 (51.3) | 239 (47.2) | 153 (51.9) | 279 (50.2) | 133 (47.7) | 159 (50.8) | 109 (56.5) |
| First-degree BCFH | 219 (21.1) | 89 (17.6) | 64 (21.7) | 99 (17.8) | 63 (22.6) | 71 (22.7) | 53 (27.5) |
| Second-degree BCFH Only | 313 (30.1) | 150 (29.6) | 89 (30.2) | 180 (32.4) | 70 (25.1) | 88 (28.1) | 56 (29.0) |
BMI body mass index, SD standard deviation.