Table 2.
Associations of measures of breast cancer family history (BCFH) with pubertal outcomes; LEGACY Girls Study
| Odds ratio (95% confidence interval) | ||||||
|---|---|---|---|---|---|---|
| Breast Tanner stage T2 + a | Pubic hair Tanner stage T2 + a | Post-menarche statusb | ||||
| Measures of BCFHc | Model 1d | Model 2e | Model 1d | Model 2e | Model 1d | Model 2f |
| n = 801 | n = 786 | n = 835 | n = 819 | n = 506 | n = 493 | |
| Any BCFH | 1.35 (0.92–1.98) |
1.36 (0.88–2.10) |
0.83 (0.58–1.20) |
0.81 (0.55–1.20) |
0.69 (0.42–1.14) |
0.69 (0.38–1.23) |
| First-degree BCFH | 1.05 (0.63–1.75) |
0.99 (0.58–1.68) |
0.98 (0.60–1.58) |
0.94 (0.58–1.55) |
0.66 (0.35–1.25) |
0.67 (0.32–1.38) |
| Second-degree BCFH Only | 1.60 (1.03–2.50) |
1.80 (1.07–3.05) |
0.76 (0.50–1.16) |
0.75 (0.48–1.17) |
0.74 (0.41–1.32) |
0.72 (0.35–1.47) |
aModels exclude girls aged ≥13 years (n = 135)
bExcludes girls aged <10 years (n = 510)
cNo BCFH is the referent group for all models
dAdjusted for age
eAdjusted for age, body mass index (BMI), race/ethnicity, and study site
fAdjusted for age, BMI, race/ethnicity, site, and BMI × age