Table 4.
The associations of weight and height with pubertal outcomes, by breast cancer family history (BCFH)
| Odds ratio (95% confidence interval) | |||
|---|---|---|---|
| Overall | BCFH+ girls | BCFH– girls | |
| Breast Tanner stage T2 + a | |||
| n | 786 | 383 | 403 |
| Model 1c | |||
| Weight (per 1 kg) | 1.09 (1.05–1.12) | 1.06 (1.03–1.10) | 1.14 (1.04–1.24) |
| Height (per 1 cm) | 1.03 (0.99–1.07) | 1.03 (0.99–1.08) | 1.01 (0.94–1.09) |
| Race/ethnicity | |||
| Non-Hispanic white | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Asian | 0.55 (0.22–1.41) | 0.66 (0.18–2.37) | 0.55 (0.16–1.86) |
| Black | 3.88 (1.74–8.65) | 5.04 (1.21–20.94) | 3.80 (1.43–10.11) |
| Hispanic | 1.18 (0.65–2.13) | 1.34 (0.58–3.14) | 0.91 (0.37–2.25) |
| Mixed race/ethnicity | 2.54 (0.75–8.54) | 7.61 (0.11–533.98) | 1.81 (0.56–5.78) |
| Model 2d | |||
| Overweight (≥85th percentile) | 4.65 (2.58–8.38) | 3.32 (1.43–7.69) | 6.72 (2.70–16.74) |
| Pubic hair Tanner stage T2 + a | |||
| n | 819 | 403 | 416 |
| Model 1c | |||
| Weight (per 1 kg) | 1.02 (0.99–1.05) | 1.02 (0.98–1.06) | 1.02 (0.98–1.06) |
| Height (per 1 cm) | 1.06 (1.03–1.10) | 1.05 (1.00–1.11) | 1.07 (1.02–1.12) |
| Race/ethnicity | |||
| Non-Hispanic white | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Asian | 0.44 (0.21–0.95) | 0.39 (0.13–1.20) | 0.46 (0.17–1.24) |
| Black | 5.27 (2.38–11.65) | 9.58 (2.53–36.19) | 3.88 (1.48–10.17) |
| Hispanic | 1.55 (0.85–2.84) | 1.71 (0.65–4.47) | 1.36 (0.60–3.11) |
| Mixed race/ethnicity | 1.46 (0.37–5.77) | 2.45 (0.54–11.05) | 1.09 (0.16–7.53) |
| Model 2d | |||
| Overweight (≥85th percentile) | 1.24 (0.75–2.06) | 1.26 (0.56–2.83) | 1.40 (0.71–2.75) |
| Post-menarche statusb | |||
| n | 493 | 260 | 233 |
| Model 1c | |||
| Weight (per 1 kg) | 1.08 (1.04–1.12) | 1.09 (1.03–1.16) | 1.06 (1.00–1.12) |
| Height (per 1 cm) | 1.03 (0.99–1.08) | 0.98 (0.93–1.05) | 1.09 (1.03–1.16) |
| Race/ethnicity | |||
| Non-Hispanic white | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Asian | 1.06 (0.46–2.45) | 0.52 (0.15–1.81) | 1.60 (0.46–5.58) |
| Black | 1.69 (0.65–4.40) | 1.37 (0.34–5.51) | 2.07 (0.50–8.54) |
| Hispanic | 2.41 (1.15–5.04) | 1.22 (0.49–3.09) | 8.08 (2.24–29.19) |
| Mixed race/ethnicity | 2.21 (0.20–23.96) | 0.29 (0.02–3.51) | 5.28 (0.06–480.69) |
| Model 2d | |||
| Overweight (≥85th percentile) | 4.19 (2.15–8.14) | 4.75 (2.08–10.82) | 3.73 (1.21–11.51) |
aExcludes girls aged ≥13 years (n = 135)
bExcludes girls aged <10 years (n = 510)
cModel includes weight, height, race/ethnicity, and is adjusted for age and study site. Non-Hispanic white is the referent race/ethnicity
dModel includes overweight and is adjusted for height, race/ethnicity, age, and study site. Non-Hispanic white is the referent race/ethnicity