Table 5.
The associations of weight and height with breast development among girls aged 5–7 years old at first visit using Weibull longitudinal models; LEGACY Girls Study
| Hazard ratio (95% confidence interval) | |||
|---|---|---|---|
| Overall | BCFH+ girls | BCFH– girls | |
| Breast Tanner stage T2+ | |||
| n | 248 | 127 | 121 |
| Model 1a | |||
| Weight (per 1 kg) | 1.05 (1.03–1.08) | 1.05 (1.02–1.08) | 1.10 (1.03–1.17) |
| Height (per 1 cm) | 1.01 (0.98–1.04) | 0.99 (0.95–1.02) | 0.98 (0.93–1.04) |
| Race/ethnicity | |||
| Non-Hispanic white | 1 (reference) | 1 (reference) | 1 (reference) |
| Asian | 1.12 (0.54–2.35) | 1.18 (0.35–3.98) | 1.31 (0.53–3.25) |
| Black | 1.31 (0.73–2.37) | 1.36 (0.76–2.42) | 1.51 (0.56–4.08) |
| Hispanic | 1.52 (0.95–2.44) | 2.75 (1.48–5.11) | 0.88 (0.37–2.08) |
| Model 2b | |||
| Overweight (≥85th percentile) | 3.61 (2.16–6.02) | 2.02 (0.99–4.11) | 9.40 (4.94–17.91) |
BCFH breast cancer family history
aModel is adjusted for age as the underlying time scale and includes weight, height, and race/ethnicity. Mixed race/ethnicity is excluded due to small cell counts
bModel is adjusted for age as the underlying time scale and includes overweight, height, and race/ethnicity. Mixed race/ethnicity is excluded due to small cell counts