Table 2.
The univariate and multivariate analysis of risk factors associated with poor immune recovery following the use of HAART for 48 months
| Predictive factor | CD4 recovery at 48 months | Unadjusted | Adjusted | |||
|---|---|---|---|---|---|---|
| Inadequate recovery (CD4 < 350) | Adequate recovery (CD4 > 350) | OR (95% CI) | P value | OR(95% CI) | P value | |
| Gender | ||||||
| Male | 117 (39.26) | 083 (28.14) | ||||
| Female | 181 (60.74) | 212 (71.86) | 1.65 (1.17–2.33) | 0.004 | 1.52 (1.02–2.27) | 0.039 |
| Age (years) | ||||||
| >50 | 227 (76.17) | 274 (92.88) | ||||
| ≤50 | 071 (23.83) | 021 (07.12) | 4.1 (2.43–6.84) | 0.000 | 4.17 (2.31–50) | 0.000 |
| Occupation | ||||||
| Employed | 032 (10.74) | 034 (11.53) | ||||
| Unemployed | 266 (89.26) | 261 (88.47) | – | – | – | – |
| WHO stage | ||||||
| Stage 1 and 2 | 105 (35.23) | 139 (47.12) | ||||
| Stage 3 and 4 | 193 (64.77) | 156 (52.88) | 1.64 (1.18–2.28) | 0.003 | 1.47 (1.01–2.14) | 0.043 |
| Baseline CD4 | ||||||
| <200 cells/µl | 260 (88.44) | 187 (64.71) | ||||
| ≥200 cells/µl | 034 (11.56) | 102 (35.29) | 4.17 (2.71–6.42) | 0.000 | 4.32 (2.70–6.90) | 0.000 |
| Baseline BMI | ||||||
| Underweight | 10 (31.25) | 09 (27.27) | ||||
| Normalweight | 22 (68.75) | 20 (60.61) | ||||
| Overweight | – | 04 (12.12) | 0.92 (0.78–1.10) | 0.332 | ||
| Obese | 264 (88.59) | – | ||||
| Opportunistic INF | ||||||
| Yes | 212 (71.14) | 118 (40.00) | ||||
| No | 086 (28.86) | 177 (60.00) | 3.69 (2.63–5.20) | 0.000 | 3.91 (2.69–5.69) | 0.000 |
| Type of OI | ||||||
| TB | 169 (79.72) | 104 (85.95) | ||||
| Others (D, C) | 043 (20.28) | 017 (14.05) | 1.56 (0.84–2.87) | 0.157 | ||
D diarrhea, C candidiasis, TB tuberculosis, BMI Body Mass Index, WHO World Health Organization, INF infection, OI opportunistic infection, OR odds ratio