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. 2017 Jun 9;5:43. doi: 10.1186/s40478-017-0441-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Pedigree of family PED.1499. The family segregates the SORL1 variant c.5195G > C (p.Gly1732Ala) in one generation. Individual (II:2) included in the EU EOD case-control study is marked with an *. The genetic status for variant c.5195G > C is indicated “carrier” for heterozygotes, “wildtype” when absent, and “unknown” if DNA was unavailable. NPH = normal pressure hydrocephalus. Onset refers to first observation of dementia symptoms, and APOE indicates the ε-alleles. The age at last known affection status of individuals still alive is indicated in parenthesis