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. 2017 Jun 9;5:43. doi: 10.1186/s40478-017-0441-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Immunohistochemical localization of SORL1 in postmortem brain material from controls, sporadic AD and PED.25. Representative pictures from control (a-c), sporadic AD (d-f) and PED.25 (g-i) in the CA1 region of hippocampus (a-b, d-e, g-h) and subcortical white matter in frontal cortex (c, f, i) using two different SORL1 antibodies, AF5699 (a, d, g) and MAB5699 (b-c, e-f, h-i). The AF5699 SORL1 antibody showed an intense immunoreactivity of extracellular SORL1 aggregates in PED.25 (arrows in g). Arrowheads indicate strong SORL1 immunoreactivity (MAB5699) in glial cells in grey (h) and white matter (i) in the affected member from PED.25. Scalebar: 50 μm. Ctrl = control, sAD = sporadic AD, PED.25 = affected family member II:6